OUTSMARTING TROGOCYTOSIS TO BOOST CAR NK/T CELL THERAPY

Outsmarting trogocytosis to boost CAR NK/T cell therapy

auren3 Abstract Chimeric antigen receptor (CAR) NK and T cell therapy are promising immunotherapeutic approaches for the treatment of cancer.However, the efficacy of CAR NK/T cell therapy is often hindered by various factors, including the phenomenon of trogocytosis, which involves the bidirectional exchange of membrane fragments between cells.In t

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Quantifying the fragility of coral reefs to hurricane impacts: a case study of the Florida Keys and Puerto Rico

Ecosystems like coral reefs mitigate rising coastal flood risks, but investments into their conservation remain low relative to the investments into engineered risk-mitigation structures.One reason is that quantifying the risk-reduction benefits bullet bill shirt of coral reefs requires an estimate of their fragility to severe stresses.Engineered s

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Amino acid polymorphisms in human histocompatibility leukocyte antigen class II and proinsulin epitope have impacts on type 1 diabetes mellitus induced by immune-checkpoint inhibitors

IntroductionImmune-checkpoint inhibitors are effective in various advanced cancers.Type 1 diabetes mellitus induced by them (ICI-T1DM) is a serious complication requiring prompt insulin treatment, but the immunological mechanism behind it is unclear.MethodsWe examined amino acid polymorphisms in human histocompatibility leukocyte antigen (HLA) mole

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